Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9373438 | 0.90 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 | |
| SCHEMBL26962664 | 0.81 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 | |
| SCHEMBL9377530 | 0.79 | BCHE (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 | |
| SCHEMBL9372161 | 0.79 | PCSK9 (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 | |
| SCHEMBL1121515 | 0.78 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 | |
| SCHEMBL9373400 | 0.77 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 | |
| SCHEMBL9378763 | 0.76 | RAB9A (0.47) | NPC1RAB9AMAPT | |
| SCHEMBL6706533 | 0.75 | CA12 (0.46) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL10958225 | 0.74 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 | |
| SCHEMBL30101615 | 0.74 | PCSK9 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398427-B1 | Antirhinoviral pyridazinamines | JANSSEN PHARMACEUTICA NV (BE) | 1994-03-16 | — | — | EP | disclosed |
| US-5112825-A | Antirhinoviral heteroamine-substituted pyridazines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-05-12 | — | — | US | disclosed |
| EP-0398427-A1 | Antirhinoviral pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-11-22 | — | — | EP | disclosed |