Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9695063 | 0.98 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| Hydrochloric Acid SCHEMBL10562883 | 0.79 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL23691408 | 0.77 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL9381251 | 0.77 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2KDM4ECYP1A2 | |
| Hydrochloric Acid SCHEMBL10564648 | 0.75 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL9377015 | 0.75 | KDM4E (0.50) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL9695261 | 0.73 | MAPT (0.56) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL28002004 | 0.73 | PDE10A (0.78) | CYP1A2CYP2D6MAPTLMNAKMT2A | |
| SCHEMBL19204573 | 0.72 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| Hydrochloric Acid SCHEMBL9695852 | 0.72 | MAPT (0.54) | NPC1RAB9ASMN1; SMN2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1261387-A | — | — | None | — | — | JP | disclosed |
| EP-0338346-B1 | Quinoxaline derivatives and antiulcer agents | NISSHIN FLOUR MILLING CO (JP) | 1994-11-30 | — | — | EP | disclosed |
| US-5106976-A | Antisecretory agents | NIPPON CHEMIPHAR CO., LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| EP-0234690-B1 | SULFOXIDE DERIVATIVES AND THEIR PREPARATION | NIPPON CHEMIPHAR CO., LTD. (JP) | 1991-05-15 | — | — | EP | disclosed |
| US-4933458-A | ANTISECRETORY AGENTS | NIPPON CHEMIPHAR CO., LTD. (JP) | 1990-06-12 | — | — | US | disclosed |
| US-4933342-A | Quinoxaline derivatives and antiulcer agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0338346-A2 | Quinoxaline derivatives and antiulcer agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-10-25 | — | — | EP | disclosed |
| JP-H01261387-A | NOVEL QUINOXALINE DERIVATIVE AND ANTIULCER AGENT CONTAINING SAID DERIVATIVE | NISSHIN FLOUR MILLING CO LTD | 1989-10-18 | — | — | JP | disclosed |
| EP-0234690-A1 | Sulfoxide derivatives and their preparation | NIPPON CHEMIPHAR CO., LTD. (JP) | 1987-09-02 | — | — | EP | disclosed |