Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 16/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.67 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mizolastine SCHEMBL6273027 | 0.89 | HRH1 (0.84) | HRH1CYP2D6KCNH2CHRM1HTR3A | |
| SCHEMBL10337963 | 0.88 | HRH1 (0.67) | HRH1CYP2D6KCNH2CHRM1HTR3A | |
| SCHEMBL9371586 | 0.81 | HRH1 (0.61) | HRH1CYP2D6KCNH2CHRM1HTR3A | |
| SCHEMBL18388464 | 0.79 | HRH1 (0.78) | HRH1CYP2D6KCNH2CHRM1HTR3A | |
| SCHEMBL5225966 | 0.77 | HRH1 (0.77) | HRH1CYP2D6KCNH2CHRM1HTR3A | |
| SCHEMBL12930743 | 0.76 | HRH1 (0.69) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12930701 | 0.76 | HRH1 (0.71) | HRH1CYP2D6KCNH2CHRM1HTR3A | |
| SCHEMBL12930707 | 0.75 | HRH1 (0.70) | HRH1CYP2D6KCNH2CHRM1HTR3A | |
| SCHEMBL20697482 | 0.75 | HRH1 (0.70) | HRH1CYP2D6KCNH2CHRM1ADRA2A | |
| SCHEMBL12930734 | 0.75 | HRH1 (0.70) | HRH1CYP2D6KCNH2CHRM1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217700-B1 | Benzimidazole derivatives, their preparation and their therapeutical use | SYNTHELABO (FR) | 1994-03-30 | — | — | EP | claimed |
| US-4820710-A | ANTIALLERGENS, ANTIHISTAMINES, ANTIINFLAMMATORY AGENTS | SYNTHELABO (FR) | 1989-04-11 | — | — | US | claimed |