Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 11/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.61 |
| ▸ | HTR3A | P46098 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273031 | 0.89 | HRH1 (0.59) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL10337965 | 0.87 | HTR3A (0.47) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL9376971 | 0.81 | HRH1 (0.72) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL5225964 | 0.77 | HRH1 (0.55) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| Mizolastine SCHEMBL6273027 | 0.70 | HRH1 (0.84) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL10337963 | 0.69 | HRH1 (0.67) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL15568527 | 0.69 | HRH1 (0.66) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL10337877 | 0.68 | HRH1 (0.74) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL15568620 | 0.67 | HRH1 (0.63) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL15963187 | 0.67 | MAPT (0.64) | HRH1CYP2D6KCNH2HTR3ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217700-B1 | Benzimidazole derivatives, their preparation and their therapeutical use | SYNTHELABO (FR) | 1994-03-30 | — | — | EP | claimed |
| US-4820710-A | ANTIALLERGENS, ANTIHISTAMINES, ANTIINFLAMMATORY AGENTS | SYNTHELABO (FR) | 1989-04-11 | — | — | US | claimed |