Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CPB1 | P15086 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29816738 | 0.86 | KMT2A (0.49) | SMN1; SMN2NPC1RAB9AHTTNPSR1 | |
| SCHEMBL19313922 | 0.86 | KMT2A (0.49) | SMN1; SMN2NPC1RAB9AHTTNPSR1 | |
| SCHEMBL20886535 | 0.86 | KMT2A (0.49) | SMN1; SMN2NPC1RAB9AHTTNPSR1 | |
| SCHEMBL15743850 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHTR2CALDH1A1 | |
| SCHEMBL8290690 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AHTR2CALDH1A1 | |
| SCHEMBL4387495 | 0.84 | KDM4E (0.51) | SMN1; SMN2NPC1RAB9AHTTNPSR1 | |
| SCHEMBL3845188 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ANPSR1HTR2C | |
| SCHEMBL3600148 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ANPSR1HTR2C | |
| SCHEMBL3600152 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ANPSR1HTR2C | |
| SCHEMBL4388871 | 0.82 | NPSR1 (0.56) | SMN1; SMN2RAB9AHTTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353778-B1 | Pyrrolo[1,4]benzodiazepine derivatives | SHIONOGI & CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-4923984-A | TREATMENT OF SENILE DEMENTIA, PSYCHONEUROSIS, AMNESIA | SHIONOGI & CO., LTD. (JP) | 1990-05-08 | — | — | US | disclosed |
| EP-0353778-A2 | Pyrrolo[1,4]benzodiazepine derivatives | SHIONOGI & CO., LTD. (JP) | 1990-02-07 | — | — | EP | disclosed |