Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 6/20 | 0.74 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.74 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.74 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9380197 | 0.98 | ADRA2A (0.72) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10533453 | 0.88 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9380851 | 0.86 | ADRA2A (0.72) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9379739 | 0.85 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL9378300 | 0.85 | ADRA2A (0.70) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Bromide SCHEMBL9379332 | 0.84 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9378965 | 0.82 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9379393 | 0.82 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9378713 | 0.82 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL10466192 | 0.81 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344982-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1994-11-23 | — | — | EP | claimed |
| US-4978660-A | 2-SUBSTITUTED-3,4,5,6-TETRAHYDROFURO(4,3,2-EF)(3)BENZAZEPINE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-18 | — | — | US | claimed |
| WO-1989012051-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | claimed |
| EP-0344982-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1994-11-23 | — | — | EP | disclosed |
| US-4978660-A | 2-SUBSTITUTED-3,4,5,6-TETRAHYDROFURO(4,3,2-EF)(3)BENZAZEPINE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |
| WO-1989012051-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | disclosed |
| EP-0344982-A2 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1989-12-06 | — | — | EP | disclosed |