Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383599 | 0.88 | P4HTM (0.45) | VHLCYP2A6KDM4EL3MBTL1MAPT | |
| SCHEMBL9384708 | 0.85 | CES2 (0.55) | VHLCYP2A6CD274PDCD1CYP2E1 | |
| SCHEMBL9383573 | 0.85 | KDM4E (0.38) | VHLCYP2A6KDM4EL3MBTL1MAPT | |
| SCHEMBL9379022 | 0.83 | LOX (0.54) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL9383881 | 0.80 | KDM4E (0.45) | CYP2A6KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL9379150 | 0.79 | KDM4E (0.56) | CYP2A6KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL9379582 | 0.77 | MIF (0.46) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL9385752 | 0.77 | KDM4E (0.46) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL9378591 | 0.77 | KDM4E (0.46) | KDM4EL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL9379617 | 0.77 | CES2 (0.39) | CYP2A6KDM4EL3MBTL1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269030-B1 | Lipid-peroxide formation inhibiting composition and novel compounds useful therefor | MITSUBISHI CHEM IND (JP) | 1994-05-04 | — | — | EP | disclosed |
| US-5089515-A | Antiischemic agents; pyrazolone compounds | MITSUBISHI KASEI CORPORATION (JP) | 1992-02-18 | — | — | US | disclosed |
| US-4990619-A | Cardiovascular disorders, antiischemic agents | MITSUBISHI KASEI CORPORATION (JP) | 1991-02-05 | — | — | US | disclosed |
| US-4906644-A | Lipid-peroxide formation inhibiting composition and novel compounds useful therefor | MITSUBISHI KASEI CORPORATION (JP) | 1990-03-06 | — | — | US | disclosed |