Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.68 |
| ▸ | CNR1 | P21554 | 1/20 | 0.68 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.68 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.56 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.56 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.56 |
| ▸ | GABRP | O00591 | 3/20 | 0.56 |
| ▸ | GABRD | O14764 | 3/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.56 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.56 |
| ▸ | GABRE | P78334 | 3/20 | 0.56 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.56 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.56 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.56 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10747106 | 0.86 | PDE4D (0.71) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL9383698 | 0.84 | CHRM1 (0.68) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL21129434 | 0.84 | PDE4D (0.68) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL10149934 | 0.82 | PDE4D (0.76) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL29354494 | 0.81 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL31000330 | 0.81 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL78453 | 0.81 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| Nordazepam SCHEMBL8090999 | 0.81 | PDE4D (1.00) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL15704731 | 0.81 | PDE4D (0.64) | PDE4DCNR1NTSR1OPRK1GABRA1 | |
| SCHEMBL11543658 | 0.81 | GABRA1 (0.78) | PDE4DCNR1NTSR1OPRK1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320992-B1 | Triazolodiazepine derivatives | HOFFMANN LA ROCHE (CH) | 1994-07-27 | — | — | EP | disclosed |
| US-4959361-A | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists | HOFFMANN-LA ROCHE INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0320992-A2 | Triazolodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-21 | — | — | EP | disclosed |