Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8364531 | 0.82 | MAPKAPK2 (0.40) | KCNH2CYP19A1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL3748867 | 0.82 | PDE4A (0.48) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22310226 | 0.82 | PDE4A (0.48) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27450288 | 0.82 | PDE4A (0.54) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4314558 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL30638906 | 0.81 | KCNH2 (0.46) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL243235 | 0.79 | PDE4A (0.45) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22309076 | 0.78 | ALDH1A1 (0.49) | PDE4APDE4BPDE4CPDE4DCYP19A1 | |
| SCHEMBL3746738 | 0.76 | PDE4A (0.46) | KCNH2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6609392 | 0.76 | MAPKAPK2 (0.43) | KCNH2CYP19A1MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289380-B1 | Aryl-heteroaryl-carbinol derivatives having an analgesic activity | ESTEVE LABOR DR (ES) | 1994-12-28 | — | — | EP | claimed |
| WO-2016124139-A1 | HETEROCYCLIC-SUBSTITUTED N-SULFONYLBENZAMIDE DERIVATIVES, PREPARATION METHOD FOR DERIVATIVES, AND PHARMACEUTICAL USE OF DERIVATIVES | 上海海雁医药科技有限公司 | 2016-08-11 | — | — | WO | disclosed |