Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380427 | 1.00 | MEN1 (0.60) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL28091426 | 0.88 | MAPT (0.57) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL3921874 | 0.87 | MAPT (0.67) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL6505926 | 0.86 | KDM4E (0.51) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL28224152 | 0.84 | MEN1 (0.60) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL8877160 | 0.82 | MEN1 (0.57) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL13939604 | 0.82 | MAPT (0.57) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL8877165 | 0.82 | MEN1 (0.57) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL2572526 | 0.82 | MAPT (0.57) | MEN1KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL9735963 | 0.79 | MEN1 (0.50) | MEN1KMT2ALMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303446-B1 | Pyrroloisoquinolines | MAY & BAKER LTD (GB) | 1994-05-25 | — | — | EP | disclosed |
| US-4933350-A | Pyrroloisoquinolines useful as hypercholesterolemic and hyperlipoprotienimic agents | MAY & BAKER LIMITED (GB) | 1990-06-12 | — | — | US | disclosed |
| EP-0303446-A1 | Pyrroloisoquinolines | MAY & BAKER LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |