Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.43 |
| ▸ | TUBB | P07437 | 8/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380429 | 1.00 | ALOX5 (0.52) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9381663 | 0.92 | ALOX5 (0.47) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9381670 | 0.92 | ALOX5 (0.47) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9380715 | 0.87 | ALOX5 (0.58) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9380717 | 0.87 | ALOX5 (0.58) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9380499 | 0.84 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL9380504 | 0.84 | ALOX5 (0.60) | ALOX5 | |
| SCHEMBL9385603 | 0.84 | ALOX5 (0.55) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9385597 | 0.84 | ALOX5 (0.55) | ALOX5TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9381668 | 0.82 | ALOX5 (0.53) | ALOX5MAPK1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |