Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 4/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9376120 | 0.80 | PGR (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2PGR | |
| SCHEMBL9376580 | 0.80 | KDM4E (0.42) | KDM4EALDH1A1MAPTSMN1; SMN2PGR | |
| SCHEMBL9376117 | 0.77 | MAPT (0.40) | KDM4EALDH1A1MAPTSMN1; SMN2PGR | |
| SCHEMBL10373369 | 0.77 | AR (0.38) | KDM4EALDH1A1MAPTPGRCLK2 | |
| SCHEMBL24112743 | 0.75 | PGR (0.46) | KDM4EMAPTPGRACVR1BMPR1B | |
| SCHEMBL13091038 | 0.75 | PGR (0.46) | KDM4EMAPTPGRACVR1BMPR1B | |
| SCHEMBL27581885 | 0.74 | KDM4E (0.38) | KDM4EALDH1A1MAPTSMN1; SMN2PGR | |
| SCHEMBL2239581 | 0.74 | PGR (0.45) | MAPTPGRACVR1BMPR1BBMPR1A | |
| SCHEMBL13734072 | 0.74 | PGR (0.60) | PGRACVR1BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL24112918 | 0.74 | PGR (0.60) | PGRACVR1BMPR1BBMPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344634-B1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-03-30 | — | — | EP | disclosed |
| US-5019587-A | Anticoagulants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-05-28 | — | — | US | disclosed |
| CN-1038640-A | Two ring carboxamide, its preparation methods and contain the pharmaceutical composition of this material | BOEHRINGER MANNHEIM GMBH (DE) | 1990-01-10 | — | — | CN | disclosed |
| EP-0344634-A1 | Bicyclic carboxamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1989-12-06 | — | — | EP | disclosed |