Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.61 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.61 |
| ▸ | TRPV6 | Q9H1D0 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975576 | 0.86 | CHRNB2 (0.59) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT | |
| SCHEMBL2037248 | 0.86 | CHRNB2 (0.59) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL8052496 | 0.85 | CHRNB2 (0.58) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT | |
| SCHEMBL14197746 | 0.83 | CHRNB2 (0.59) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT | |
| SCHEMBL6398126 | 0.83 | CHRNB2 (0.59) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT | |
| SCHEMBL6399377 | 0.83 | CHRNB2 (0.59) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT | |
| SCHEMBL5015324 | 0.83 | CHRNB2 (0.68) | CHRNB2CHRNA4TRPV6ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL61401 | 0.81 | CHRNB2 (0.66) | CHRNB2CHRNA4TRPV6ALDH1A1KDM4E | |
| SCHEMBL23291215 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT | |
| SCHEMBL23291216 | 0.81 | CHRNB2 (0.56) | CHRNB2CHRNA4TRPV6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140030223-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-8569302-B2 | Inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| EP-2475657-B1 | 5-ALKINYLTHIEN-2-YLCARBOXYLIC ACIDS AS INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2013-06-12 | — | — | EP | disclosed |
| US-20110020278-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140030223-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | CHRNB2 4880/4885CHRNA4 4852/4885TRPV6 4636/4885 |
| US-20110020278-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | CHRNB2 4880/4885CHRNA4 4852/4885TRPV6 4636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.