Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616279 | 0.89 | POLB (0.39) | POLBPPARDALDH1A1TSHRCYP2C9 | |
| SCHEMBL6837614 | 0.87 | PPARD (0.38) | POLBPPARDTSHRCYP2C9CYP2C19 | |
| SCHEMBL1051880 | 0.87 | POLB (0.53) | POLBALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL10847001 | 0.85 | POLB (0.41) | POLBALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL25277788 | 0.84 | POLB (0.40) | POLBALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL3675752 | 0.84 | POLB (0.43) | POLBALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL1052265 | 0.82 | POLB (0.40) | POLBALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL8532180 | 0.82 | POLB (0.40) | POLBALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL9000615 | 0.82 | POLB (0.42) | POLB | |
| SCHEMBL11346348 | 0.82 | L3MBTL1 (0.46) | POLBALDH1A1TSHRCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344979-B1 | Alfa-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1994-11-09 | — | — | EP | disclosed |
| US-4963547-A | HYPOTENSIVE AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-10-16 | — | — | US | disclosed |
| WO-1989012054-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | disclosed |
| WO-1989012050-A1 | alpha-ADRENERGIC RECEPTOR ANTAGONISTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-12-14 | — | — | WO | disclosed |
| EP-0344980-A2 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0344979-A2 | Alfa-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1989-12-06 | — | — | EP | disclosed |