Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.79 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380993 | 1.00 | ALOX5 (0.79) | ALOX5HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL9379916 | 0.91 | ALOX5 (0.83) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL9379914 | 0.91 | ALOX5 (0.83) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL9385668 | 0.90 | ALOX5 (0.81) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL9385670 | 0.90 | ALOX5 (0.81) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL9195116 | 0.89 | ALOX5 (1.00) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL9195122 | 0.89 | ALOX5 (1.00) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL9382168 | 0.88 | ALOX5 (0.78) | ALOX5HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL9382171 | 0.88 | ALOX5 (0.78) | ALOX5HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL9387034 | 0.87 | ALOX5 (0.98) | ALOX5HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |