Ormetoprim

Ormetoprim

SCHEMBL93810

COc1cc(C)c(Cc2cnc(N)nc2N)cc1OC

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 2/20 0.69
P2RX2 Q9UBL9 2/20 0.69
DHFR P00374 3/20 0.64
HTT P42858 1/20 0.64
MEN1 O00255 1/20 0.62
SLC22A1 O15245 1/20 0.62
ALDH1A1 P00352 1/20 0.62
CYP3A4 P08684 1/20 0.62
TSHR P16473 1/20 0.62
NFKB1 P19838 1/20 0.62
CYP2C19 P33261 1/20 0.62
BLM P54132 1/20 0.62
KMT2A Q03164 1/20 0.62
HSD17B10 Q99714 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ormetoprim SCHEMBL29389444 1.00 P2RX3 (0.69) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL11555328 0.91 P2RX3 (0.81) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL328871 0.88 P2RX3 (0.72) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL1494157 0.85 P2RX3 (0.73) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL30215873 0.85 P2RX3 (0.73) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL2150300 0.84 P2RX3 (0.67) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL2150191 0.83 P2RX3 (0.70) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL11559756 0.82 P2RX3 (0.65) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL1494010 0.82 P2RX3 (1.00) P2RX3P2RX2DHFRHTTMEN1
SCHEMBL29384647 0.82 P2RX3 (1.00) P2RX3P2RX2DHFRHTTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1713 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230193225-A1 NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS AIX-MARSEILLE UNIVERSITE (FR) 2023-06-22 US claimed
CN-112034054-B Method for detecting content of olmeprin in aquatic product 厦门鉴科检测技术有限公司 2022-09-02 CN claimed
WO-2022046930-A1 ANTIVIRAL AND ANTIMICROBIAL PROTECTIVE FILMS WITH MICROSTRUCTURE DETERRENTS LUMENCO, LLC (US) 2022-03-03 WO claimed
US-20220063178-A1 ANTIVIRAL AND ANTIMICROBIAL PROTECTIVE FILMS WITH MICROSTRUCTURE DETERRENTS COMBINED WITH THERMALLY ELASTOMERIC AND EMBEDDED CHEMICAL ANTI-BACTERIAL OR ANTI-VIRAL AGENTS MICROBEPROOF, LLC 2022-03-03 US claimed
US-20220048979-A1 TREATMENT OF STAPHYLOCOCCAL DISORDERS THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERAN AFFAIRS 2022-02-17 US claimed
EP-3941206-A1 NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS Fondation Méditerranée Infection (FR) 2022-01-26 EP claimed
CN-112034054-A Method for detecting content of olmeprin in aquatic product 厦门鉴科检测技术有限公司 2020-12-04 CN claimed
WO-2020187861-A1 NEW USES OF A MUTATED LACTONASE, AND COMPOSITIONS FONDATION MEDITERRANEE INFECTION (FR) 2020-09-24 WO claimed
EP-2953624-B1 METHODS OF TREATING MICROBIAL INFECTIONS, INCLUDING MASTITIS LUODA PHARMA LTD (IE) 2019-08-21 EP claimed
CN-109432106-A A kind of compound sulfonamide chlorine pyridazine and preparation method thereof 镇江威特药业有限责任公司 2019-03-08 CN claimed
CN-1441790-A Enhanced propertied pharmaceuticals ROHM & HAAS (US) 2003-09-10 CN claimed
EP-1272463-A1 ENHANCED PROPERTIED PHARMACEUTICALS ROHM AND HAAS COMPANY (US) 2003-01-08 EP claimed
WO-2001054481-A2 ENHANCED PROPERTIED PHARMACEUTICALS ROHM AND HAAS COMPANY (US) 2001-08-02 WO claimed
US-6211185-B1 ADMINISTERING ORALLY WITH DRINKING WATER VETERINARY PHARMACY CORPORATION 2001-04-03 US claimed
US-5258373-A SYNERGISTIC MIXTURE OF SULFADIMETHOXINE, ORMETOPRIM AND FRENOLICIN-B HOFFMANN-LA ROCHE INC. (US) 1993-11-02 US claimed
EP-0523529-A2 Anticoccidial compositions F. HOFFMANN-LA ROCHE AG (CH) 1993-01-20 EP claimed
US-5135924-A For non-humans; canines, bovines, equines; treating systemic bacterial infections HOFFMANN-LA ROCHE INC. (US) 1992-08-04 US claimed
US-5063219-A Anticoccidial composition HOFFMANN-LA ROCHE INC. (US) 1991-11-05 US claimed
US-4996198-A Mixture of 2,4-diamino-5-(trisubstituted)benzyl-pyrimidine potentiated sulfonamide antibiotic with an ionophorous polyether HOFFMANN-LA ROCHE INC. (US) 1991-02-26 US claimed
US-4599416-A Process for the preparation of aqueous solutions of potentiated sulfonamides HOFFMANN-LA ROCHE INC. (US) 1986-07-08 US claimed