Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.62 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9381234 | 1.00 | ALOX5 (0.62) | ALOX5HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL9387228 | 0.86 | HTR2A (0.50) | ALOX5HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL9387227 | 0.86 | HTR2A (0.50) | ALOX5HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL9384141 | 0.85 | ALOX5 (0.59) | ALOX5HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL9380158 | 0.85 | HTR2C (0.50) | ALOX5HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL9384139 | 0.85 | ALOX5 (0.59) | ALOX5HTR2CHTR2BHTR2AALDH1A1 | |
| SCHEMBL7969809 | 0.85 | ALOX5 (0.62) | ALOX5HTR2CHTR2BHTR2ASLC6A2 | |
| SCHEMBL7971059 | 0.85 | ALOX5 (0.62) | ALOX5HTR2CHTR2BHTR2A | |
| SCHEMBL7971054 | 0.85 | ALOX5 (0.62) | ALOX5HTR2CHTR2BHTR2A | |
| SCHEMBL7969804 | 0.85 | ALOX5 (0.62) | ALOX5HTR2CHTR2BHTR2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |