Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18329485 | 0.85 | MEN1 (0.45) | CYP3A4ACHEMEN1KMT2AKDM4E | |
| SCHEMBL8124185 | 0.83 | SRD5A2 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL24445654 | 0.83 | THRB (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1495242 | 0.83 | CYP3A4 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1018937 | 0.81 | MEN1 (0.42) | CYP3A4ACHEMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17926378 | 0.80 | CA12 (0.52) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8507372 | 0.79 | HPGD (0.43) | MCL1CYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL24680130 | 0.79 | FABP3 (0.44) | MEN1KMT2ASMN1; SMN2MAPK1METAP2 | |
| SCHEMBL30933127 | 0.78 | CA1 (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3738298 | 0.78 | CA12 (0.50) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409484-B1 | 4,5,6,7-Tetrasubstituted benzoxazolones | PFIZER (US) | 1994-06-08 | — | — | EP | disclosed |
| US-5071863-A | Antiallergens; antiinflammatory agents; enzyme inhibitors | PFIZER INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0409484-A2 | 4,5,6,7-Tetrasubstituted benzoxazolones | PFIZER INC. (US) | 1991-01-23 | — | — | EP | disclosed |