Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.61 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384460 | 1.00 | ALOX5 (0.61) | ALOX5KDM1AMAOAMAOBHTR2C | |
| SCHEMBL9380206 | 0.89 | ALOX5 (0.60) | ALOX5SLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL9380200 | 0.89 | ALOX5 (0.60) | ALOX5SLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL9385399 | 0.88 | ALOX5 (0.46) | ALOX5KDM1AMAOAMAOBHTR2C | |
| SCHEMBL9385395 | 0.88 | ALOX5 (0.46) | ALOX5KDM1AMAOAMAOBHTR2C | |
| SCHEMBL9380387 | 0.86 | ALOX5 (0.80) | ALOX5KDM1AMAPT | |
| SCHEMBL9380392 | 0.86 | ALOX5 (0.80) | ALOX5KDM1AMAPT | |
| SCHEMBL9380156 | 0.85 | ALOX5 (0.65) | ALOX5HTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9380154 | 0.85 | ALOX5 (0.65) | ALOX5HTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9380906 | 0.83 | ALOX5 (0.64) | ALOX5KDM1AMAOAMAOBHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |