Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17662643 | 0.81 | JMJD6 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23862586 | 0.79 | KDM1A (0.42) | KDM1ACYP19A1JMJD6HCRTR2 | |
| SCHEMBL18222497 | 0.78 | CYP19A1 (0.44) | KDM1ACYP19A1JMJD6SMN1; SMN2HTT | |
| SCHEMBL23345448 | 0.76 | CYP19A1 (0.39) | KDM1ACYP19A1JMJD6 | |
| SCHEMBL2629335 | 0.75 | — | — | |
| SCHEMBL21468656 | 0.72 | KDM1A (0.38) | KDM1ACYP19A1JMJD6EPHX2SMN1; SMN2 | |
| SCHEMBL24792887 | 0.72 | EPHX2 (0.42) | CYP19A1JMJD6EPHX2 | |
| SCHEMBL26392658 | 0.71 | KDM1A (0.36) | KDM1ACYP19A1JMJD6SMN1; SMN2HTT | |
| SCHEMBL4613310 | 0.71 | KMT2A (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23345429 | 0.70 | KDM1A (0.37) | KDM1ACYP19A1JMJD6SMN1; SMN2HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0389189-B1 | Diazepine antiallergy agents | PFIZER LTD (GB) | 1994-05-18 | — | — | EP | claimed |
| EP-0389189-A2 | Diazepine antiallergy agents | Pfizer Limited (GB) | 1990-09-26 | — | — | EP | claimed |
| EP-0389189-B1 | Diazepine antiallergy agents | PFIZER LTD (GB) | 1994-05-18 | — | — | EP | disclosed |
| EP-0389189-A2 | Diazepine antiallergy agents | Pfizer Limited (GB) | 1990-09-26 | — | — | EP | disclosed |