Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2629335 | 0.79 | — | — | |
| SCHEMBL7810321 | 0.78 | — | — | |
| SCHEMBL21468722 | 0.77 | DYRK1A (0.37) | — | |
| SCHEMBL18222561 | 0.74 | CYP19A1 (0.40) | KDM1ACYP19A1KMT2AKEAP1SIGMAR1 | |
| SCHEMBL17662643 | 0.74 | JMJD6 (0.43) | KDM1ACYP19A1KMT2AKEAP1SIGMAR1 | |
| SCHEMBL18222497 | 0.74 | CYP19A1 (0.44) | KDM1ACYP19A1KMT2AKEAP1SIGMAR1 | |
| SCHEMBL21438893 | 0.73 | HTT (0.32) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL9384706 | 0.72 | TDP1 (0.41) | KDM1ACYP19A1EPHX2JMJD6HTT | |
| SCHEMBL12970421 | 0.72 | PKM (0.59) | KDM1AKMT2AEPHX2JMJD6SMN1; SMN2 | |
| SCHEMBL19121810 | 0.72 | CYP19A1 (0.38) | KDM1ACYP19A1KMT2AKEAP1JMJD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019200246-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR | ABELA ALEXANDER RUSSELL (US) | 2019-10-17 | — | — | WO | disclosed |