Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878042 | 0.83 | PDE4B (0.31) | PDE4BPDE4D | |
| SCHEMBL10572882 | 0.80 | PDE4B (0.30) | PDE4BPDE4D | |
| SCHEMBL9877552 | 0.80 | NSD2 (0.31) | — | |
| SCHEMBL9384614 | 0.77 | TNKS (0.31) | PDE4BPDE4D | |
| SCHEMBL7389179 | 0.77 | TNKS (0.33) | PDE4BPDE4D | |
| SCHEMBL10570359 | 0.76 | HTR2C (0.42) | PDE4BPDE4D | |
| SCHEMBL11035315 | 0.74 | KDM4E (0.35) | PDE4BPDE4D | |
| SCHEMBL9386510 | 0.73 | — | — | |
| SCHEMBL18403954 | 0.72 | — | — | |
| SCHEMBL9382754 | 0.71 | HTR2C (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276057-B1 | Piperazinylpyrimidines as beta-adrenergic receptor blocking agents | MERCK & CO INC (US) | 1994-03-09 | — | — | EP | disclosed |
| US-4994464-A | Treatment of elevated intraocular pressure and glaucoma | MERCK & CO., INC. (US) | 1991-02-19 | — | — | US | disclosed |
| US-4889856-A | INTRAOCULAR PRESSURE REDUCTION; CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0276057-A2 | Piperazinylpyrimidines as beta-adrenergic receptor blocking agents | MERCK & CO. INC. (US) | 1988-07-27 | — | — | EP | disclosed |