Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.52 |
| ▸ | LMNA | P02545 | 8/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9385206 | 1.00 | ALDH1A1 (0.52) | ALDH1A1LMNAGAACYP19A1SMN1; SMN2 | |
| SCHEMBL9389886 | 0.98 | ALDH1A1 (0.53) | ALDH1A1LMNAGAACYP19A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL9384198 | 0.92 | ALDH1A1 (0.51) | ALDH1A1LMNAGAACYP19A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL9389131 | 0.92 | ALDH1A1 (0.51) | ALDH1A1LMNAGAACYP19A1SMN1; SMN2 | |
| SCHEMBL9387156 | 0.90 | ALDH1A1 (0.52) | ALDH1A1LMNAGAACYP19A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL9383801 | 0.87 | ALDH1A1 (0.69) | ALDH1A1LMNAGAASMN1; SMN2MAPT | |
| Oxalic Acid SCHEMBL9383793 | 0.87 | ALDH1A1 (0.69) | ALDH1A1LMNAGAASMN1; SMN2MAPT | |
| SCHEMBL9386127 | 0.85 | ALDH1A1 (0.72) | ALDH1A1LMNAGAASMN1; SMN2MAPT | |
| Oxalic Acid SCHEMBL9384720 | 0.84 | ALDH1A1 (0.48) | ALDH1A1LMNAGAASMN1; SMN2MAPT | |
| Oxalic Acid SCHEMBL9384716 | 0.84 | ALDH1A1 (0.48) | ALDH1A1LMNAGAASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369627-B1 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5008267-A | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0369627-A2 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-05-23 | — | — | EP | disclosed |