Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30297960 | 1.00 | GAA (0.47) | GAAMAPK1POLBPDE5APDE4A | |
| SCHEMBL26685153 | 0.83 | RPS6KA5 (0.53) | GAAMAPK1PDE5APDE4APDE1A | |
| SCHEMBL28469348 | 0.79 | POLB (0.46) | GAAMAPK1POLBSMN1; SMN2HTR7 | |
| SCHEMBL19337066 | 0.78 | RPS6KA5 (0.61) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL28460368 | 0.75 | POLB (0.46) | POLBSMN1; SMN2HTR7RPS6KA5RAB9A | |
| SCHEMBL28459603 | 0.75 | POLB (0.46) | GAAMAPK1POLBHTR7MAPT | |
| SCHEMBL28679956 | 0.75 | POLB (0.46) | GAAMAPK1POLBHTR7MAPT | |
| SCHEMBL31107087 | 0.75 | CDC7 (0.60) | POLBMAPTRPS6KA5RAB9AALDH1A1 | |
| SCHEMBL524138 | 0.75 | CDC7 (0.60) | POLBMAPTRPS6KA5RAB9AALDH1A1 | |
| SCHEMBL29388549 | 0.75 | CDC7 (0.60) | POLBMAPTRPS6KA5RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994002145-A2 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | GENELABS TECHNOLOGIES, INC. (US) | 1994-02-03 | — | — | WO | disclosed |