Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.59 |
| ▸ | DHFR | P00374 | 3/20 | 0.59 |
| ▸ | ATIC | P31939 | 4/20 | 0.46 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.46 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9382833 | 1.00 | GART (0.59) | GARTDHFRATICFOLR2FOLR1 | |
| SCHEMBL9387634 | 1.00 | GART (0.59) | GARTDHFRATICFOLR2FOLR1 | |
| SCHEMBL9382816 | 1.00 | GART (0.59) | GARTDHFRATICFOLR2FOLR1 | |
| SCHEMBL9388635 | 0.94 | DHFR (0.54) | GARTDHFRATICFOLR2FOLR1 | |
| SCHEMBL9383773 | 0.94 | DHFR (0.54) | GARTDHFRATICFOLR2FOLR1 | |
| Lometrexol SCHEMBL9045915 | 0.88 | GART (0.75) | GARTDHFRATIC | |
| Lometrexol SCHEMBL12022771 | 0.88 | GART (0.75) | GARTDHFRATIC | |
| SCHEMBL7487513 | 0.85 | GART (0.71) | GARTDHFRATIC | |
| SCHEMBL8820483 | 0.85 | GART (0.60) | GARTDHFRATICFOLR2FOLR1 | |
| SCHEMBL7488545 | 0.85 | GART (0.71) | GARTDHFRATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343801-B1 | N-(5,6,7,8-tetrahydropyrido(2,3-D)pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1994-08-03 | — | — | EP | claimed |
| US-4882334-A | ANTITUMOR AGENTS INHIBIT ENZYMES WHICH USE FOLIC ACID OR ITS METABOLITES AS SUBSTRATE; ANTICARCINOGENIC | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-11-21 | — | — | US | claimed |