Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777634 | 0.82 | USP2 (0.43) | RECQLTSHRSMN1; SMN2ATM | |
| SCHEMBL10692712 | 0.80 | L3MBTL1 (0.53) | L3MBTL1RECQLTSHRALDH1A1POLB | |
| SCHEMBL505705 | 0.76 | L3MBTL1 (0.51) | L3MBTL1RECQLTSHRALDH1A1POLB | |
| SCHEMBL10694845 | 0.76 | L3MBTL1 (0.51) | L3MBTL1RECQLTSHRALDH1A1POLB | |
| SCHEMBL9985346 | 0.75 | MAPT (0.40) | ALDH1A1KDM4EMAPT | |
| SCHEMBL895343 | 0.73 | L3MBTL1 (0.55) | L3MBTL1RECQLTSHRALDH1A1POLB | |
| SCHEMBL9179839 | 0.73 | L3MBTL1 (0.49) | L3MBTL1RECQLTSHRALDH1A1POLB | |
| SCHEMBL5911872 | 0.73 | L3MBTL1 (0.49) | L3MBTL1RECQLTSHRALDH1A1POLB | |
| SCHEMBL9175037 | 0.73 | L3MBTL1 (0.49) | L3MBTL1RECQLTSHRALDH1A1POLB | |
| SCHEMBL9175215 | 0.72 | L3MBTL1 (0.48) | L3MBTL1RECQLTSHRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994000456-A1 | SPIROFURANE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | FISONS CORPORATION (US) | 1994-01-06 | — | — | WO | disclosed |
| EP-0491562-A1 | Novel spirofurane derivatives | FISONS CORPORATION (US) | 1992-06-24 | — | — | EP | disclosed |
| US-5075317-A | 2,8-dimethyl-1-oxa-8-azospiro(4.5) decan-3-one; alzheimer*s di sease | FISONS CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |