Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7494463 | 0.99 | MAPK14 (0.41) | MAPK14L3MBTL1MAPK11KCNH2RIPK3 | |
| SCHEMBL7491064 | 0.88 | MAPK14 (0.43) | MAPK14MAPK11KCNH2RIPK3CSNK1A1 | |
| SCHEMBL7499669 | 0.87 | MAPK14 (0.46) | MAPK14MAPK11KCNH2RIPK3CSNK1A1 | |
| SCHEMBL7491823 | 0.86 | MAPK14 (0.47) | MAPK14MAPK11KCNH2RIPK3CSNK1A1 | |
| SCHEMBL7487399 | 0.86 | MAPK14 (0.45) | MAPK14MAPK11KCNH2RIPK3CSNK1A1 | |
| SCHEMBL9219500 | 0.86 | THRB (0.42) | MAPK14L3MBTL1MAPK11MAPK13MAPK12 | |
| SCHEMBL7492880 | 0.85 | MAPK14 (0.43) | MAPK14MAPK11KCNH2CSNK1A1CSNK1D | |
| SCHEMBL7499637 | 0.85 | MAPK14 (0.43) | MAPK14MAPK11KCNH2RIPK3CSNK1A1 | |
| SCHEMBL7494396 | 0.85 | MAPK14 (0.44) | MAPK14MAPK11KCNH2RIPK3CSNK1A1 | |
| SCHEMBL7488387 | 0.85 | MAPK14 (0.48) | MAPK14MAPK11KCNH2CSNK1A1CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994019350-A1 | PYRAZOLITRIAZINES WITH INTERLEUKIN-1 AND TUMOUR NECROSIS FACTOR INHIBITORY ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |