Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307976 | 0.88 | TSHR (0.41) | TSHRACACBZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL515064 | 0.87 | TSHR (0.40) | TSHRACACBZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL16594934 | 0.84 | TSHR (0.44) | TSHRACACBZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL1517529 | 0.79 | TSHR (0.39) | TSHRACACBZDHHC20ZDHHC2 | |
| SCHEMBL9396211 | 0.78 | TGFBR1 (0.39) | — | |
| SCHEMBL2494021 | 0.77 | TSHR (0.44) | TSHRACACBZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL29264597 | 0.77 | TSHR (0.47) | TSHRACACBZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL851108 | 0.76 | TSHR (0.37) | TSHRACACBZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL4245910 | 0.76 | TSHR (0.42) | TSHRACACBZDHHC20ZDHHC2ALDH1A1 | |
| SCHEMBL1517421 | 0.71 | CYP2C19 (0.38) | TSHRACACBALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0387706-B1 | Oxygen permeable hard contact lens | KURARAY CO (JP) | 1994-10-26 | — | — | EP | disclosed |
| US-5162391-A | Copolymer of Siloxanyalkylacrylamide of a Fluoro Monomer | KURARAY CO., LTD. (JP) | 1992-11-10 | — | — | US | disclosed |
| EP-0387706-A2 | Oxygen permeable hard contact lens | KURARAY CO., LTD. (JP) | 1990-09-19 | — | — | EP | disclosed |