Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9396760 | 0.88 | POLB (0.38) | PDE4DTSHRPOLBMAPT | |
| SCHEMBL9275055 | 0.87 | HDAC6 (0.38) | HDAC6CYP1A2CYP3A4GAACYP2C9 | |
| SCHEMBL9211024 | 0.85 | MEN1 (0.41) | HDAC6CYP1A2CYP3A4GAACYP2C9 | |
| SCHEMBL9396762 | 0.83 | PDE4D (0.44) | PDE4DHDAC6CYP1A2CYP3A4GAA | |
| SCHEMBL9278089 | 0.83 | PTAFR (0.42) | HDAC6CYP1A2CYP3A4GAACYP2C9 | |
| SCHEMBL9396741 | 0.82 | TSHR (0.37) | HDAC6CYP1A2CYP3A4GAACYP2C9 | |
| SCHEMBL9277582 | 0.81 | AGTR1 (0.40) | HDAC6CYP1A2CYP3A4GAACYP2C9 | |
| SCHEMBL9272528 | 0.81 | CYP1A2 (0.38) | HDAC6CYP1A2CYP3A4GAACYP2C9 | |
| SCHEMBL9274838 | 0.81 | AGTR1 (0.39) | HDAC6CYP1A2CYP3A4GAACYP2C9 | |
| SCHEMBL9203210 | 0.81 | TSHR (0.38) | CYP1A2CYP3A4GAACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994029307-A1 | PYRROLO[3,2-B]PYRIDINYLALKYL BENZAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1994-12-22 | — | — | WO | claimed |
| US-5360907-A | Platelet activating factor | G.D. SEARLE & CO. (US) | 1994-11-01 | — | — | US | claimed |
| WO-1994029307-A1 | PYRROLO[3,2-B]PYRIDINYLALKYL BENZAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5360907-A | Platelet activating factor | G.D. SEARLE & CO. (US) | 1994-11-01 | — | — | US | disclosed |