Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.44 |
| ▸ | F2R | P25116 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400567 | 0.92 | MAPT (0.67) | MAPTCNR1ACHECNR2LMNA | |
| SCHEMBL28753894 | 0.84 | MAPT (0.63) | MAPTLMNAMEN1KMT2AF2RL3 | |
| SCHEMBL3039635 | 0.77 | MAPT (0.59) | MAPTCNR1ACHECNR2LMNA | |
| SCHEMBL9400570 | 0.77 | SRC (0.46) | MAPTMEN1KMT2A | |
| SCHEMBL9400629 | 0.76 | MAPT (1.00) | MAPTLMNAMEN1KMT2AF2RL3 | |
| SCHEMBL30934812 | 0.76 | MAPT (1.00) | MAPTLMNAMEN1KMT2AF2RL3 | |
| SCHEMBL262113 | 0.74 | MAPT (0.71) | MAPTCNR1ACHECNR2LMNA | |
| SCHEMBL5012036 | 0.74 | MAPT (0.71) | MAPTCNR1ACHECNR2LMNA | |
| SCHEMBL18261960 | 0.74 | MAPT (0.71) | MAPTCNR1ACHECNR2LMNA | |
| SCHEMBL5652624 | 0.74 | MAPT (0.47) | MAPTLMNAMEN1KMT2AF2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328922-A | Anxiolytic and antidepressant activity | BEECHAM GROUP P.L.C. (GB) | 1994-07-12 | — | — | US | disclosed |
| EP-0550507-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005170-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |