Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 17/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9660558 | 0.84 | PTAFR (0.74) | PTAFR | |
| SCHEMBL8752397 | 0.78 | PTAFR (0.35) | PTAFRPDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL9660003 | 0.78 | PTAFR (0.38) | PTAFRPDE3BPDE3A | |
| SCHEMBL9662342 | 0.71 | PTAFR (0.37) | PTAFR | |
| SCHEMBL9401188 | 0.71 | PTAFR (0.58) | PTAFR | |
| SCHEMBL9859555 | 0.70 | PTAFR (1.00) | PTAFR | |
| SCHEMBL9859558 | 0.70 | PTAFR (1.00) | PTAFR | |
| SCHEMBL8752379 | 0.70 | PTAFR (1.00) | PTAFR | |
| SCHEMBL9689907 | 0.69 | PTAFR (0.96) | PTAFR | |
| SCHEMBL9689918 | 0.69 | PTAFR (0.96) | PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292946-A | Reducing agent | MERCK & CO., INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0478062-A1 | In-situ preparation of diisopinocampheyl chloroborane | MERCK & CO. INC. (US) | 1992-04-01 | — | — | EP | disclosed |
| EP-0478063-A1 | Method of making optically active alcohols | MERCK & CO. INC. (US) | 1992-04-01 | — | — | EP | disclosed |
| US-5099033-A | Condensation of bromine compound with organometallic compound to form platelet activating factor antagonist, anticoagulants, hypotensives, antiinflammatory agents and cardiovascular disorders | MERCK & CO., INC. (US) | 1992-03-24 | — | — | US | disclosed |
| EP-0465122-A1 | Process of making 2,5-diaryl tetrahydrofurans and analogs thereof useful as paf antagonists | MERCK & CO. INC. (US) | 1992-01-08 | — | — | EP | disclosed |