Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9401795 | 1.00 | KDM4E (0.56) | KDM4EMTNR1AMTNR1BMAPTNPSR1 | |
| SCHEMBL15913822 | 0.92 | MAPT (0.56) | KDM4EMTNR1AMTNR1BMAPTNPSR1 | |
| SCHEMBL29489353 | 0.92 | MAPT (0.56) | KDM4EMTNR1AMTNR1BMAPTNPSR1 | |
| SCHEMBL3826539 | 0.84 | KDM4E (0.55) | KDM4EMTNR1AMTNR1BMAPTNPSR1 | |
| SCHEMBL10854687 | 0.84 | MEN1 (0.55) | KDM4EMTNR1AMTNR1BMAPTALDH1A1 | |
| SCHEMBL10376845 | 0.84 | MEN1 (0.55) | KDM4EMTNR1AMTNR1BMAPTALDH1A1 | |
| SCHEMBL10662062 | 0.84 | KDM4E (0.52) | KDM4EMTNR1AMTNR1BMAPTHDAC8 | |
| SCHEMBL7384130 | 0.80 | MAPT (0.53) | MAPTNPSR1ALDH1A1LMNAMEN1 | |
| SCHEMBL7384129 | 0.80 | MAPT (0.53) | MAPTNPSR1ALDH1A1LMNAMEN1 | |
| SCHEMBL29138776 | 0.79 | MTNR1A (0.51) | KDM4EMTNR1AMTNR1BMAPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286869-A | Vasodilators and anticoagulants | FUJIREBIO KABUSHIKI KAISHA (JP) | 1994-02-15 | — | — | US | disclosed |
| EP-0403957-A2 | Optical active 1,4-dihydropyridine derivates | FUJIREBIO INC. (JP) | 1990-12-27 | — | — | EP | disclosed |
| US-4621082-A | Pyridopyrimidines, pharmaceutical compositions and use | BAYER AKTIENGESELLSCHAFT (DE) | 1986-11-04 | — | — | US | disclosed |