Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | APAF1 | O14727 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MPO | P05164 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855506 | 0.91 | SMN1; SMN2 (0.74) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL29156414 | 0.89 | KDM4E (0.62) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL4989677 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL2406326 | 0.85 | KDM4E (0.69) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL4987528 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL9449541 | 0.83 | SMN1; SMN2 (0.77) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL29367542 | 0.82 | KDM4E (0.69) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL22357157 | 0.82 | KDM4E (0.69) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL8244909 | 0.82 | KDM4E (0.69) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL1833783 | 0.82 | KDM4E (0.69) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334606-A | Analgesics, antiinflammatory agents | MERCK SHARPE & DOHME LTD. (GB) | 1994-08-02 | — | — | US | disclosed |
| EP-0545478-A1 | Heterocyclic compounds as tachykinin antagonists | MERCK SHARP & DOHME LTD. (GB) | 1993-06-09 | — | — | EP | disclosed |