Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.49 |
| ▸ | RARB | P10826 | 3/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402602 | 1.00 | PLA2G2A (0.66) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402726 | 0.95 | PLA2G2A (0.60) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402720 | 0.93 | PLA2G2A (0.69) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402521 | 0.92 | PLA2G2A (0.57) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402692 | 0.92 | PLA2G2A (0.56) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402564 | 0.91 | PLA2G2A (0.56) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402794 | 0.91 | PLA2G2A (0.55) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402638 | 0.90 | PLA2G2A (0.55) | PLA2G2ABLMTP53TSHRPLA2G4B | |
| SCHEMBL9402764 | 0.89 | PLA2G2A (0.54) | PLA2G2ABLMPLA2G4BSMPD1 | |
| SCHEMBL9402818 | 0.88 | PLA2G2A (0.53) | PLA2G2ABLMTP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | claimed |
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |