Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402538 | 1.00 | PTPN11 (0.54) | PTPN11MAOAMAOBPLA2G2APLA2G4B | |
| SCHEMBL9402875 | 1.00 | PTPN11 (0.54) | PTPN11MAOAMAOBPLA2G2APLA2G4B | |
| SCHEMBL9324880 | 0.94 | PTPN11 (0.51) | PTPN11MAOAMAOBPLA2G2APLA2G4B | |
| SCHEMBL9402810 | 0.93 | NPC1 (0.51) | LRRK2 | |
| SCHEMBL22439018 | 0.92 | PTPN11 (0.55) | PTPN11MAOAMAOBPLA2G2APLA2G4B | |
| SCHEMBL22438874 | 0.92 | PTPN11 (0.55) | PTPN11MAOAMAOBPLA2G2APLA2G4B | |
| SCHEMBL9402543 | 0.90 | PTPN11 (0.53) | PTPN11MAOAMAOBPLA2G2APLA2G4B | |
| SCHEMBL9402524 | 0.90 | HDAC3 (0.52) | PLA2G2A | |
| SCHEMBL9402747 | 0.89 | PTPN11 (0.64) | PTPN11PLK1TSHR | |
| SCHEMBL9402749 | 0.89 | PTPN11 (0.64) | PTPN11PLK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |