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Morphine

Morphine

SCHEMBL940320

CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1

The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 known ✓ P35372 6/20 1.00
▸ OPRD1 P41143 11/20 1.00
▸ OPRK1 P41145 5/20 1.00
▸ MRGPRX2 Q96LB1 2/20 0.90
▸ SLC22A1 O15245 1/20 0.90
▸ ADRA2A P08913 1/20 0.90
▸ ARRB1 P49407 1/20 0.90

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Morphine SCHEMBL3061897 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL3477364 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL29316 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL30885818 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL29317 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL1559600 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL8512218 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL8512204 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL2030143 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1
Morphine SCHEMBL8090431 1.00 OPRD1 (1.00) OPRD1OPRM1OPRK1MRGPRX2SLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11285112-B2 Abuse resistant forms of immediate release oxymorphone, method of use and method of making Oheno Life Sciences, Inc (US) 2022-03-29 — — US disclosed
US-11191730-B2 Abuse resistant forms of immediate release hydromorphone, method of use and method of making OHEMO LIFE SCIENCES INC. (US) 2021-12-07 — — US disclosed
US-11045422-B2 Abuse resistant drugs, method of use and method of making OHENO LIFE SCIENCES, INC. (US) 2021-06-29 — — US disclosed
US-10736850-B2 Abuse resistant oral opioid formulations OHEMO LIFE SCIENCES INC. (US) 2020-08-11 — — US disclosed
US-10736851-B2 Abuse resistant forms of extended release morphine with oxycodone, method of use and method of making OHEMO LIFE SCIENCES INC. (US) 2020-08-11 — — US disclosed
US-10736852-B2 Abuse resistant oral opioid formulations OHEMO Life Sciences, Inc. (US) 2020-08-11 — — US disclosed
US-10702480-B2 Abuse resistant forms of extended release morphine, method of use and method of making OHEMO Life Sciences, Inc. (US) 2020-07-07 — — US disclosed
US-10695298-B2 Abuse resistant forms of extended release hydromorphone, method of use and method of making INSPIRION DELIVERY SCIENCES, LLC (US) 2020-06-30 — — US disclosed
US-10688051-B2 Abuse resistant forms of extended release oxycodone, method of use, and method of making INSPIRION DELIVERY SCIENCES LLC (US) 2020-06-23 — — US disclosed
US-10688054-B2 Abuse resistant forms of extended release morphine, method of use and method of making INSPIRION DELIVERY SCIENCES LLC (US) 2020-06-23 — — US disclosed
US-20110159089-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-30 — — US disclosed
US-20110159090-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-30 — — US disclosed
US-20110150970-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-23 — — US disclosed
US-20110150971-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-23 — — US disclosed
US-20110150969-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-23 — — US disclosed
US-20110150990-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-23 — — US disclosed
US-20110150991-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-23 — — US disclosed
US-7955619-B2 Abuse resistant drugs, method of use and method of making INSPIRION DELIVERY TECHNOLOGIES, LLC (US) 2011-06-07 — — US disclosed
US-20110076325-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING ABUSE DETERRENT PHARMACEUTICAL, LLC (US) 2011-03-31 — — US disclosed
US-20110002985-A1 ABUSE RESISTANT DRUGS, METHOD OF USE AND METHOD OF MAKING ABUSE DETERRENT PHARMACEUTICAL, LLC (US) 2011-01-06 — — US disclosed