Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11006206 | 0.86 | TDP1 (0.56) | TDP1TSHRGPR35ALDH1A1LMNA | |
| SCHEMBL29903867 | 0.79 | TSHR (0.58) | TDP1TSHRALDH1A1LMNACYP3A4 | |
| SCHEMBL10788183 | 0.79 | TSHR (0.58) | TDP1TSHRALDH1A1LMNACYP3A4 | |
| SCHEMBL8688741 | 0.76 | TDP1 (0.66) | TDP1TSHRGPR35ALDH1A1LMNA | |
| SCHEMBL31447779 | 0.75 | TDP1 (0.52) | TDP1TSHRALDH1A1LMNACYP3A4 | |
| SCHEMBL8686354 | 0.75 | TDP1 (0.52) | TDP1TSHRALDH1A1LMNACYP3A4 | |
| SCHEMBL30738237 | 0.74 | TDP1 (0.62) | TDP1TSHRALDH1A1LMNACYP3A4 | |
| SCHEMBL1826053 | 0.74 | TDP1 (0.62) | TDP1TSHRGPR35ALDH1A1LMNA | |
| SCHEMBL30503606 | 0.74 | TDP1 (0.62) | TDP1TSHRGPR35ALDH1A1LMNA | |
| SCHEMBL29415362 | 0.74 | TSHR (0.55) | TDP1TSHRGPR35ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0349219-B1 | 1,2,4,5-benzoylenebis(naphtho[1,8-de]pyrimidine) compounds and their use | SHARP KK (JP) | 1994-10-05 | — | — | EP | disclosed |
| US-5116706-A | As charge generating component | SHARP KABUSHIKI KAISHA (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0349219-A1 | 1,2,4,5-benzoylenebis(naphtho[1,8-de]pyrimidine) compounds and their use | SHARP KABUSHIKI KAISHA (JP) | 1990-01-03 | — | — | EP | disclosed |