Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.53 |
| ▸ | HTR3B | O95264 | 3/20 | 0.50 |
| ▸ | HTR3A | P46098 | 3/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4090399 | 0.82 | ABCB1 (0.57) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL9404476 | 0.82 | KDM4E (0.50) | SMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL5320912 | 0.79 | HTR3B (0.69) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL1084086 | 0.79 | MEN1 (0.69) | HRH4ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL11740107 | 0.78 | HTR3B (0.68) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL2536412 | 0.74 | HTR3B (0.62) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL21637847 | 0.72 | SMN1; SMN2 (0.48) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL3679992 | 0.72 | HRH4 (0.61) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL29343953 | 0.71 | SMN1; SMN2 (0.54) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL25720390 | 0.71 | SMN1; SMN2 (0.47) | HRH4HTR3BHTR3AHTR3EHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |