Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726482 | 0.86 | HRH4 (0.50) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9404544 | 0.82 | HRH4 (0.53) | KDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9404540 | 0.79 | ALOX15 (0.49) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4095134 | 0.79 | KDM4E (0.69) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2725738 | 0.78 | PIK3CA (0.54) | PIK3CA | |
| SCHEMBL7930954 | 0.77 | SMN1; SMN2 (0.49) | KDM4EMAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7326820 | 0.77 | POLB (0.53) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2725946 | 0.76 | PIK3CA (0.49) | PIK3CAAURKARPS6KB1CNR2 | |
| SCHEMBL16094600 | 0.75 | PIK3CA (0.60) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1309823 | 0.75 | LMNA (0.73) | KDM4EMAPTSMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371080-A | Central nervous system disorders | NOVO NORDISK A/S | 1994-12-06 | — | — | US | disclosed |
| EP-0619820-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993013103-A1 | IMIDAZOQUINAZOLINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-07-08 | — | — | WO | disclosed |