Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404707 | 1.00 | CYP11B1 (0.61) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4112665 | 0.84 | CYP11B1 (0.59) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4112664 | 0.84 | CYP11B1 (0.59) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL12375861 | 0.83 | CES2 (0.56) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL25832729 | 0.83 | CPT1B (0.47) | CYP11B1CYP11B2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9475635 | 0.82 | CYP11B1 (0.58) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL19835872 | 0.81 | CYP11B1 (0.61) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL21049318 | 0.81 | CYP11B1 (0.61) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16847938 | 0.81 | CES2 (0.54) | CYP11B1CYP11B2SMN1; SMN2ALDH1A1CES2 | |
| SCHEMBL8798863 | 0.81 | CES2 (0.54) | SMN1; SMN2ALDH1A1MEN1KMT2ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329940-B1 | 5-(substituted)amino)-8- (phenyl or substituted phenyl)-3H,6H-1,2,5,a,8 a-tetraazaacenaphthylen-3-ones | AMERICAN CYANAMID CO (US) | 1994-01-05 | — | — | EP | disclosed |
| US-4916137-A | 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |