Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404804 | 0.89 | NPC1 (0.43) | KDM4EMAPTLMNAACHEHPGD | |
| SCHEMBL1828068 | 0.75 | KDM4E (0.38) | KDM4EMAPTLMNAACHEHPGD | |
| SCHEMBL9404766 | 0.71 | KDM4E (0.44) | KDM4EMAPTLMNAACHEHPGD | |
| SCHEMBL6413455 | 0.71 | KDM4E (0.39) | KDM4EMAPTLMNAACHEHPGD | |
| SCHEMBL3158365 | 0.68 | KDM4E (0.56) | KDM4EMAPTLMNAACHEHPGD | |
| SCHEMBL9404907 | 0.68 | KDM4E (0.44) | KDM4EMAPTLMNAACHEHPGD | |
| SCHEMBL3674074 | 0.67 | CA9 (0.50) | KDM4EMAPTACHEHPGDALDH1A1 | |
| SCHEMBL30701949 | 0.67 | CA9 (0.50) | KDM4EMAPTACHEHPGDALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28905550 | 0.67 | KDM4E (0.55) | KDM4EMAPTLMNAACHEHPGD | |
| SCHEMBL301029 | 0.66 | NPC1 (0.41) | KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0313081-B1 | 2-Oxa-isocephem compounds, compositions containing the same and processes for preparing the same | OTSUKA PHARMA CO LTD (JP) | 1994-02-02 | — | — | EP | disclosed |
| US-4950662-A | ANTIBIOTIC | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-21 | — | — | US | disclosed |
| EP-0313081-A2 | 2-Oxa-isocephem compounds, compositions containing the same and processes for preparing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-26 | — | — | EP | disclosed |