Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404837 | 0.99 | ALOX15 (0.64) | ALOX15TRPV1TOP2AADRB2ADRA2A | |
| SCHEMBL9404934 | 0.95 | ALOX15 (0.59) | ALOX15TRPV1TOP2AADRB2ADRA2A | |
| SCHEMBL9404969 | 0.93 | ALOX15 (0.63) | ALOX15TRPV1TOP2AADRB2ADRA2A | |
| SCHEMBL9404949 | 0.91 | ALOX15 (0.64) | ALOX15TRPV1TOP2AADRB2ADRA2A | |
| SCHEMBL9405000 | 0.90 | ALOX15 (0.62) | ALOX15TRPV1ADRB2ADRA2ADRD2 | |
| SCHEMBL9404953 | 0.87 | ALOX15 (0.59) | ALOX15TRPV1TOP2AADRB2ADRA2A | |
| SCHEMBL15559065 | 0.87 | ALOX15 (0.72) | ALOX15TRPV1TOP2ACYP1A2CYP3A4 | |
| SCHEMBL15557423 | 0.87 | ALOX15 (0.72) | ALOX15TRPV1TOP2ACYP1A2CYP3A4 | |
| SCHEMBL15557936 | 0.87 | ALOX15 (0.72) | ALOX15TRPV1TOP2ACYP1A2CYP3A4 | |
| SCHEMBL15558282 | 0.87 | ALOX15 (0.72) | ALOX15TRPV1TOP2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431942-B1 | Percutaneously absorbable pharmaceutical preparation containing dopamine derivative | SANSHO CO (JP) | 1994-03-23 | — | — | EP | disclosed |
| US-5246949-A | And lactic acid esters, treatment of hypotension and cardiac circulatory insufficiency | SANSHO CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0431942-A2 | Percutaneously absorbable pharmaceutical preparation containing dopamine derivative | SANSHO CO., LTD. (JP) | 1991-06-12 | — | — | EP | disclosed |