Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HRH2 | P25021 | 8/20 | 0.50 |
| ▸ | HRH1 | P35367 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21428430 | 0.95 | POLB (0.58) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL22018193 | 0.93 | POLB (0.57) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL20943327 | 0.93 | POLB (0.57) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL9405372 | 0.92 | POLB (0.73) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL7034033 | 0.89 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL5594520 | 0.85 | POLB (0.65) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL14590615 | 0.85 | POLB (0.65) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL27826063 | 0.85 | SMN1; SMN2 (0.65) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL3634052 | 0.85 | SMN1; SMN2 (0.69) | POLBSMN1; SMN2LMNAHRH2HRH1 | |
| SCHEMBL1859157 | 0.85 | SMN1; SMN2 (0.69) | POLBSMN1; SMN2LMNAHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189606-B1 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RES & DEV (IL) | 2007-08-15 | — | — | EP | claimed |
| US-6855711-B1 | Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-02-15 | — | — | US | claimed |
| EP-3518334-B1 | NON-AQUEOUS ELECTROLYTE SOLUTION ADDITIVE, NON-AQUEOUS ELECTROLYTE SOLUTION FOR LITHIUM SECONDARY BATTERY AND LITHIUM SECONDARY BATTERY COMPRISING SAID ADDITIVE | LG CHEMICAL LTD (KR) | 2021-04-21 | — | — | EP | disclosed |
| EP-3778571-A1 | (2E,4E)-5-PHENYL-PENTA-2,4-DIEN-1-ONE DERIVATIVE | Bioway, Inc. (KR) | 2021-02-17 | — | — | EP | disclosed |
| EP-3322706-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-11-11 | — | — | EP | disclosed |
| US-20200157048-A1 | (2E,4E)-5-PHENYL-PENTA-2,4-DIEN-1-ONE DERIVATIVE | BIOWAY., INC (KR) | 2020-05-21 | — | — | US | disclosed |
| WO-2019190177-A1 | (2E,4E)-5-PHENYL-PENTA-2,4-DIEN-1-ONE DERIVATIVE | 주식회사 바이오웨이 | 2019-10-03 | — | — | WO | disclosed |
| US-20170267685-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2017-09-21 | — | — | US | disclosed |
| US-9695132-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-07-04 | — | — | US | disclosed |
| US-9663524-B2 | Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors | CELGENE CAR LLC (BM) | 2017-05-30 | — | — | US | disclosed |
| US-20160009733-A1 | REGULATION OF NITRIC OXIDE RELEASE AND BIOFILM DEVELOPMENT | UNIVERSITY OF WOLLONGONG (AU) | 2016-01-14 | — | — | US | disclosed |
| US-7960413-B2 | Pyrazole compounds | MERCK PATENT GMBH (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20110008285-A1 | NOVEL CYCLOSPORIN ANALOGUES | ENANTA PHARMACEUTICALS, INC. | 2011-01-13 | — | — | US | disclosed |
| US-7842695-B2 | Substituted pyrazole compounds | MERCK PATENT GMBH (DE) | 2010-11-30 | — | — | US | disclosed |
| US-7566709-B2 | 1,3,4-Substituted pyrazoles as 5-HT receptor antagonists for the treatment of psychoses and neurological disorders | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| US-20080214572-A1 | Selected Tetracyclic Tetrahydrofuran Derivatives Containing a Cyclic Amine Side Chain | FERNANDEZ-GADEA FRANCISCO JAVIER | 2008-09-04 | — | — | US | disclosed |
| EP-1189606-B1 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RES & DEV (IL) | 2007-08-15 | — | — | EP | disclosed |
| US-6855711-B1 | Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2005-02-15 | — | — | US | disclosed |
| CN-1136191-C | Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists | ������ҩ������˾ | 2004-01-28 | — | — | CN | disclosed |
| CN-1301253-A | Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists | AVENTIS PHARMACEUTICAL INC (US) | 2001-06-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157048-A1 | (2E,4E)-5-PHENYL-PENTA-2,4-DIEN-1-ONE DERIVATIVE | PCK1, PCK2, ACACB | POLB 2434/4885SMN1; SMN2 4751/4885LMNA 1567/4885 |
| US-20170267685-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | PRKACA, PRKDC, AURKC | POLB 2389/4885SMN1; SMN2 4743/4885LMNA 3640/4885 |
| US-20080214572-A1 | Selected Tetracyclic Tetrahydrofuran Derivatives Containing a Cyclic Amine Side Chain | HTR2C, HTR2A, HTR5A | POLB 2932/4885SMN1; SMN2 2040/4885LMNA 4371/4885 |
| US-20160009733-A1 | REGULATION OF NITRIC OXIDE RELEASE AND BIOFILM DEVELOPMENT | NOS1, NOS2, NOS3 | POLB 3945/4885SMN1; SMN2 4885/4885LMNA 4677/4885 |
| US-20110008285-A1 | NOVEL CYCLOSPORIN ANALOGUES | HAVCR2, CHP1, TSLP | POLB 4466/4885SMN1; SMN2 3645/4885LMNA 4748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.