Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 5/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9406846 | 0.84 | POLB (0.50) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL17942857 | 0.81 | PDE3B (0.51) | POLBALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL240664 | 0.79 | NQO2 (0.57) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL5747064 | 0.79 | ALDH1A1 (0.50) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL15271481 | 0.77 | NQO2 (0.56) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL3968654 | 0.77 | NQO2 (0.50) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL5749415 | 0.77 | NQO1 (0.53) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL10333544 | 0.76 | PDE3B (0.57) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL32690198 | 0.76 | NQO2 (0.54) | POLBALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL9406609 | 0.76 | ALDH1A1 (0.60) | POLBALDH1A1KDM4ERAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0328535-B1 | THE ADMINISTRATION OF MONOAMINE ACRIDINES IN CHOLINERGIC NEURONAL DEFICIT STATES | SUMMERS WILLIAM KOOPMANS (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0595365-A1 | Pharmaceutical composition for the treatment of underlying nonpharmacologically induced nervous system cholinergic deficit state comprising monoamine acridine derivatives | Summers, William Koopmans (US) | 1994-05-04 | — | — | EP | disclosed |
| US-4816456-A | Administration of monoamine acridines in cholinergic neuronal deficit states | SUMMERS WILLIAM K (US) | 1989-03-28 | — | — | US | disclosed |