SCHEMBL9407322

SCHEMBL9407322

CC(C)COC(=O)c1cnccn1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
POLB P06746 4/20 0.54
TSHR P16473 4/20 0.54
ALDH1A1 P00352 3/20 0.51
GAA P10253 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
RECQL P46063 1/20 0.50
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 1/20 0.48
KDM4E B2RXH2 2/20 0.47
NAPRT Q6XQN6 1/20 0.47
HCAR2 Q8TDS4 1/20 0.47
KMT2A Q03164 2/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
MEN1 O00255 1/20 0.47
USP2 O75604 1/20 0.47
MAPT P10636 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15012396 0.86 POLB (0.50) POLBTSHRALDH1A1GAASMN1; SMN2
SCHEMBL15012112 0.84 RECQL (0.55) POLBTSHRALDH1A1GAASMN1; SMN2
SCHEMBL30665084 0.81 POLB (0.46) POLBTSHRALDH1A1GAASMN1; SMN2
SCHEMBL30568667 0.81 POLB (0.61) POLBTSHRALDH1A1GAASMN1; SMN2
SCHEMBL2558377 0.81 POLB (0.61) POLBTSHRALDH1A1GAASMN1; SMN2
SCHEMBL8408307 0.78 MAPT (0.63) POLBTSHRALDH1A1GAASMN1; SMN2
SCHEMBL9407292 0.77 KDM4E (0.52) POLBTSHRALDH1A1GAASMN1; SMN2
SCHEMBL31358928 0.77 TSHR (0.53) TSHRALDH1A1SMN1; SMN2KDM4EKMT2A
SCHEMBL27101915 0.77 ALDH1A1 (0.59) TSHRALDH1A1GAAKDM4ENAPRT
SCHEMBL9988330 0.75 ALDH1A1 (0.45) POLBTSHRALDH1A1GAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013084214-A2 PYRAZINOIC ACID PRODRUGS ACTIVATED BY ESTERASES OF MYCOBACTERIA UNIVERSIDADE DE LISBOA (PT) 2013-06-13 WO claimed
JP-6211811-A None JP disclosed
WO-2013084214-A2 PYRAZINOIC ACID PRODRUGS ACTIVATED BY ESTERASES OF MYCOBACTERIA UNIVERSIDADE DE LISBOA (PT) 2013-06-13 WO disclosed
JP-H06211811-A PYRAZINE-2-CARBOXYLIC ACID ESTER AND ITS PRODUCTION NIPPON SODA CO LTD 1994-08-02 JP disclosed