Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361016 | 0.79 | PIK3CD (0.39) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL1704105 | 0.78 | PIK3CD (0.58) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL12912408 | 0.77 | PIK3CD (0.44) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL13506750 | 0.75 | PIK3CD (0.40) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL938243 | 0.74 | PIK3CD (0.61) | PIK3CDPIK3R1ALDH1A2ALDH1A1ALDH1A3 | |
| SCHEMBL938576 | 0.72 | PIK3CD (1.00) | PIK3CDPIK3R1 | |
| SCHEMBL735172 | 0.70 | PIK3CG (0.42) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL10330141 | 0.67 | SMN1; SMN2 (0.38) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL3760208 | 0.64 | GAA (0.36) | ALDH1A1 | |
| SCHEMBL356167 | 0.63 | PIK3CD (0.76) | PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2011-01-27 | — | — | US | disclosed |
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2011-01-27 | — | — | US | disclosed |
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2011-01-27 | — | — | US | disclosed |
| WO-2009064802-A2 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | ELI LILLY & CO. (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021541-A1 | INHIBITORS OF HUMAN PHOSPHATIDYL-INOSITOL 3-KINASE DELTA | PIK3CD, PI4KB, PI4KA | PIK3CD 1/4885PIK3R1 22/4885PIK3CG 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.