⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717919 | 0.84 | — | — | |
| SCHEMBL16496273 | 0.81 | — | — | |
| SCHEMBL28244684 | 0.70 | — | — | |
| SCHEMBL16237326 | 0.67 | CHRNB2 (0.34) | — | |
| SCHEMBL16237824 | 0.67 | CHRNB2 (0.34) | — | |
| SCHEMBL3463114 | 0.62 | — | — | |
| SCHEMBL234698 | 0.62 | — | — | |
| SCHEMBL27467506 | 0.62 | NISCH (0.34) | — | |
| SCHEMBL24783209 | 0.61 | CHRNB2 (0.31) | — | |
| SCHEMBL22755811 | 0.60 | SLC18A3 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492199-B2 | Pyridopyrimidines as histamine H4-receptor inhibitors | FAES FARMA, S.A. (ES) | 2025-12-09 | — | — | US | disclosed |
| CN-112739699-B | Pyridopyrimidine compounds as histamine H4 receptor inhibitors | 费斯制药股份有限公司 | 2023-11-28 | — | — | CN | disclosed |
| EP-3827005-B1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA SA (ES) | 2022-08-17 | — | — | EP | disclosed |
| US-20210300922-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2021-09-30 | — | — | US | disclosed |
| EP-3827005-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2021-06-02 | — | — | EP | disclosed |
| CN-112739699-A | Pyridopyrimidine compounds as histamine H4 receptor inhibitors | 费斯制药股份有限公司 | 2021-04-30 | — | — | CN | disclosed |
| WO-2020020939-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2020-01-30 | — | — | WO | disclosed |
| EP-2914267-B1 | THERAPY FOR CONSTIPATION | LAMB BLAIR G (CA) | 2018-12-12 | — | — | EP | disclosed |
| US-9616066-B2 | Therapy for constipation | 2294719 ONTARIO LIMITED (CA) | 2017-04-11 | — | — | US | disclosed |
| US-20170065599-A9 | THERAPY FOR CONSTIPATION | 2294719 ONTARIO LIMITED (CA) | 2017-03-09 | — | — | US | disclosed |
| US-7538110-B2 | e.g. 1-(8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2- alpha ]pyrazin-2(6H)-yl)-2-phenylethanone; analgesics; gastrointestinal dysfunction, post-surgical recovery; side effect reduction | ADOLOR CORPORATION (US) | 2009-05-26 | — | — | US | disclosed |
| CN-101355951-A | Novel opioid antagonists | ADOLOR CORP (US) | 2009-01-28 | — | — | CN | disclosed |
| EP-1940412-A2 | NOVEL OPIOID ANTAGONISTS | Adolor Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1940412-A2 | NOVEL OPIOID ANTAGONISTS | Adolor Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007050802-A3 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORP (US) | 2007-11-22 | — | — | WO | disclosed |
| US-20070105863-A1 | e.g. 1-(8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2- alpha ]pyrazin-2(6H)-yl)-2-phenylethanone; analgesics; gastrointestinal dysfunction, post-surgical recovery; side effect reduction | MERCK SHARP & DOHME LLC | 2007-05-10 | — | — | US | disclosed |
| US-20070105863-A1 | e.g. 1-(8-(3-hydroxyphenyl)-7,8-dimethyl-hexahydro-1H-pyrido[1,2- alpha ]pyrazin-2(6H)-yl)-2-phenylethanone; analgesics; gastrointestinal dysfunction, post-surgical recovery; side effect reduction | MERCK SHARP & DOHME LLC | 2007-05-10 | — | — | US | disclosed |
| WO-2007050802-A2 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORPORATION (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007050802-A2 | NOVEL OPIOID ANTAGONISTS | ADOLOR CORPORATION (US) | 2007-05-03 | — | — | WO | disclosed |
| JP-2001064178-A | 2,7-SUBSTITUTED OCTAHYDRO-1H-PYRIDO[1,2-A] PYRAZINE DERIVATIVE AS A LIGAND TO SEROTONIN RECEPTOR | PFIZER PROD INC | 2001-03-13 | — | — | JP | disclosed |