SCHEMBL9409736

SCHEMBL9409736

C#CCN1C(=O)N(C(=O)OC(C)(C)C)CC1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.35
MAPT P10636 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
TSHR P16473 1/20 0.33
KDM4E B2RXH2 1/20 0.33
THRB P10828 1/20 0.33
PTPN2 P17706 1/20 0.33
PTPN1 P18031 1/20 0.33
PTPN6 P29350 1/20 0.33
CTSK P43235 1/20 0.33
HPGD P15428 1/20 0.31
CHRM2 P08172 1/20 0.31
CHRM1 P11229 1/20 0.31
CHRM3 P20309 1/20 0.31
AR P10275 1/20 0.31
GPR119 Q8TDV5 1/20 0.31
DDB1 Q16531 2/20 0.30
CRBN Q96SW2 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9409699 0.81 CHRM2 (0.52) CHRM2CHRM1CHRM3
SCHEMBL22561498 0.74 CHRM2 (0.41) NR1H2MAPTMEN1ALDH1A1KMT2A
SCHEMBL17148731 0.74 CHRM2 (0.41) NR1H2MAPTMEN1ALDH1A1KMT2A
SCHEMBL5552520 0.72 NR1H2 (0.47) NR1H2MAPTMEN1ALDH1A1KMT2A
SCHEMBL9409704 0.71 TSHR (0.34) TSHRCHRM2CHRM1CHRM3
SCHEMBL5552498 0.69 MEN1 (0.45) NR1H2MAPTMEN1ALDH1A1KMT2A
SCHEMBL29132204 0.69 MEN1 (0.45) NR1H2MAPTMEN1ALDH1A1KMT2A
SCHEMBL19382281 0.68 NR1H2 (0.41) NR1H2MAPTMEN1ALDH1A1KMT2A
SCHEMBL19382280 0.68 NR1H2 (0.41) NR1H2MAPTMEN1ALDH1A1KMT2A
SCHEMBL21838812 0.67 MAPT (0.43) NR1H2MAPTMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0605393-A1 Heterocyclic acetylenic amines having central nervous system activity THE UPJOHN COMPANY (US) 1994-07-06 EP disclosed
US-5225567-A HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY THE UPJOHN COMPANY (US) 1993-07-06 US disclosed
US-5157124-A Improving mental performance THE UPJOHN COMPANY (US) 1992-10-20 US disclosed
US-5137905-A Cholinergic agonists; analgesics; cognition activators THE UPJOHN COMPANY (US) 1992-08-11 US disclosed
EP-0440670-A1 HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. UPJOHN CO (US) 1991-08-14 EP disclosed
WO-1990004588-A1 HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY THE UPJOHN COMPANY (US) 1990-05-03 WO disclosed