Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15129360 | 0.80 | HSD17B10 (0.36) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL1710058 | 0.80 | HSD17B10 (0.36) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL483259 | 0.77 | CHRM2 (0.43) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL20406585 | 0.77 | CHRM2 (0.43) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL8269698 | 0.76 | CHRM2 (0.44) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL625885 | 0.76 | CHRM2 (0.44) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL13956844 | 0.76 | CHRM2 (0.44) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL24774089 | 0.76 | MAPK1 (0.35) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL14518852 | 0.76 | CHRM2 (0.41) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL16027794 | 0.76 | MAPK1 (0.35) | KDM4EMAPTTHRBCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0605393-A1 | Heterocyclic acetylenic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1994-07-06 | — | — | EP | disclosed |
| US-5225567-A | HETEROCYCLIC ACETYLENIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5157124-A | Improving mental performance | THE UPJOHN COMPANY (US) | 1992-10-20 | — | — | US | disclosed |
| US-5137905-A | Cholinergic agonists; analgesics; cognition activators | THE UPJOHN COMPANY (US) | 1992-08-11 | — | — | US | disclosed |