Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10490158 | 0.91 | MAPT (0.45) | MAPTGAATSHRNPSR1KDM4E | |
| SCHEMBL10914916 | 0.82 | GAA (0.40) | MAPTGAATSHRNPSR1KDM4E | |
| SCHEMBL27398624 | 0.81 | MAPT (0.53) | MAPTGAATSHRNPSR1KDM4E | |
| SCHEMBL28787105 | 0.81 | MAPT (0.53) | MAPTGAATSHRNPSR1KDM4E | |
| SCHEMBL9710472 | 0.81 | HDAC8 (0.44) | MAPTGAATSHRNPSR1DPP4 | |
| SCHEMBL28296103 | 0.80 | GAA (0.49) | MAPTGAATSHRNPSR1KDM4E | |
| SCHEMBL9252380 | 0.80 | MAPT (0.36) | MAPTGAATSHRNPSR1KDM4E | |
| SCHEMBL7806756 | 0.78 | TSHR (0.38) | MAPTGAATSHRNPSR1KDM4E | |
| SCHEMBL2498951 | 0.77 | HDAC8 (0.46) | — | |
| SCHEMBL10833719 | 0.77 | MAPT (0.45) | MAPTGAATSHRNPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618221-A2 | Heterocyclic inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-10-05 | — | — | EP | disclosed |